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component exponential function  (SYSTAT)
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Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component <t>exponential</t> decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).
Component Exponential Function, supplied by SYSTAT, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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multi-exponential function (3 components) using originpro 2021  (OriginLab corp)
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Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component <t>exponential</t> decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).
Multi Exponential Function (3 Components) Using Originpro 2021, supplied by OriginLab corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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single-component exponential decay function  (Abbott Laboratories)
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Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component <t>exponential</t> decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).
Single Component Exponential Decay Function, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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two-component exponential function  (GraphPad Software Inc)
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GraphPad Software Inc two-component exponential function
Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component <t>exponential</t> decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).
Two Component Exponential Function, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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two component exponential decay function  (GraphPad Software Inc)
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GraphPad Software Inc two component exponential decay function
Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component <t>exponential</t> decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).
Two Component Exponential Decay Function, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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three-component exponential function  (Rundo Cronova)
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Rundo Cronova three-component exponential function
Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component <t>exponential</t> decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).
Three Component Exponential Function, supplied by Rundo Cronova, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component exponential decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).

Journal: bioRxiv

Article Title: Melanopsin ganglion cells in the mouse retina independently evoke pupillary light reflex

doi: 10.1101/2024.05.14.594181

Figure Lengend Snippet: Temporal features of high light-evoked PLRs were equivalent between WT and MNU eyes: A) The initial phase of high light-evoked PLRs is displayed in a short time scale. The latency from the light stimulus onset (black dotted line) to the start of the PLR in WT eyes (blue dotted line) and MNU eyes (red dotted line) are shown. B) A summary graph shows the latency in WT and MNU eyes, which showed a significant delay (p<0.05, Student’s unpaired t-test ). The means for WT and MNU are presented in blue and red. C) The onsets of high light-evoked PLRs were fit by single component exponential decay curves for WT eyes (blue) and MNU (red) injected mice (R2>0.90). D) A scatter plot showing each curve fit’s time constant (tau). MNU exhibited low tau, indicating a faster PLR constriction phase than WT PLR (p<0.05, n=12 mice). E) A scatter plot showing peak constriction showed no differences between WT and MNU mice (p= 0.07, n=12 mice).

Article Snippet: For the analysis of the transient constriction during high light conditions, raw traces were fitted with a single component exponential function (R 2 > .90, SigmaPlot14.5, Systat).

Techniques: Injection